Friday, March 29, 2013

Mate choice in mice is heavily influenced by paternal cues, mouse study shows

Mar. 28, 2013 ? Hybrid offspring of different house mice populations show a preference for mating with individuals from their father's original population.

Mate choice is a key factor in the evolution of new animal species. The choice of a specific mate can decisively influence the evolutionary development of a species. In mice, the attractiveness of a potential mate is conveyed by scent cues and ultrasonic vocalizations. Researchers from the Max Planck Institute for Evolutionary Biology in Pl?n investigated whether house mice (Mus musculus) would mate with each other even if they were from two populations which had been separated from each other for a long time period. To do this, the researchers brought together mice from a German population and mice from a French population. Although to begin with all the mice mated with one another randomly, the hybrid offspring of French and German parents were distinctly more choosy: they showed a definite preference for mating with individuals from their father's original population. According to the researchers, this paternal imprinting accelerates the divergence of two house mouse populations and thus promotes speciation.

In allopatric speciation, individuals of a species become geographically isolated from each other by external factors such as mountains or estuaries. Over time, this geographic separation leads to the sub-populations undergoing various mutations, and thus diverging genetically. Animals from the two different sub-populations can no longer successfully reproduce, so two new species evolve.

To find out what role partner selection plays in such speciation processes, Diethard Tautz from the Max Planck Institutefor Evolutionary Biology and his colleagues conducted a comprehensive study on house mice -- the classic model organisms of biology. "To investigate whether there are differences in the mating behaviour of the mice in the early stages of speciation, we caught wild house mice in southern France and western Germany. The two populations have been geographically separate for around 3,000 years, which equates to some 18,000 generations," says Diethard Tautz. Due to this geographical separation, the French and German mice were genetically different.

The Pl?n-based researchers created a semi-natural environment for their investigations -- a sort of "Playboy Mansion" for mice. The research enclosure was several square meters in size and was divided up using wooden walls, "nests" made out of plastic cylinders, and plastic tubes. It also featured an escape tube with several entrances, which led into a cage system nearby. "We constructed the enclosure in such a way that all animals had unimpeded access to all areas, but thanks to the structural divisions were also able to create their own territories or retreat into nests," explains Tautz. "The escape tube was a control element. If the mice retreated to it only very seldom -- as was the case in our experiment -- then we could be sure there was no overpopulation in the central enclosure."

In this central enclosure, the French and German mice had both time and space to mate with each other and reproduce. "At first, all the mice mated with each other quite randomly. But with the first-generation offspring, a surprising pattern emerged," says Tautz. When the first-generation hybrid offspring of mixed French and German parentage mated, they showed a specific preference for pure-bred mates whose "nationality" was that of their father only. "There must be some kind of paternal influence that prompts the hybrid mice to choose a mate from a specific population, namely that of their father," concludes the biologist, based on the results of his study. "This imprinting must be learned, however, meaning that the animals must grow up in the presence of their fathers. This was not the case for the original mice, which were kept in cages for a time after being caught."

"We know that mice use ultrasonic vocalizations to communicate with each other and that particularly in the case of male mice these vocalizations can reveal signals of individuality and kinship. We believe that, like birdsong, the vocalizations of the males have a learned component and a genetic component," says Tautz. Therefore, French and German mice really could "speak" different languages, partly learned from their fathers, partly inherited from them. Individual mice thus have a mating preference for mice that speak the same language as they do.

The French and German mouse populations had evidently been geographically separated long enough for preliminary signs of species differentiation to be apparent as regards mating preferences. In addition, another aspect of mating behavior also sped up the speciation process. Although mice have multiple mates, the researchers found evidence of partner fidelity and inbreeding. The tendency to mate with relatives fosters the creation of genetically uniform groups. When both occur together, this accelerates the speciation process.

In a next step, Diethard Tautz wants to find out whether the vocalizations of the mice play the decisive role in paternal imprinting, or if scent cues are also involved. Furthermore, the biologist wants to identify the genes that are involved in mate selection.

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The above story is reprinted from materials provided by Max-Planck-Gesellschaft.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Inka Montero, Meike Tesche and Diethard Tautz. Paternal imprinting of mating preferences between natural populations of house mice (Mus musculus domesticus). Molecular Ecology, 2013 DOI: 10.111/mec.122271

Note: If no author is given, the source is cited instead.

Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/most_popular/~3/oUt1DL9X6YE/130328125331.htm

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Thursday, March 28, 2013

Court says gov't can be sued over guards' actions (The Arizona Republic)

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HIV test urged for 7,000 Oklahoma dental patients

This photo taken Thursday, March 28, 2013 shows the office of oral surgeon W. Scott Harrington in Tulsa, Okla. Health officials have urged Harrington?s patients to undergo hepatitis and HIV testing, saying filthy conditions at his office posed a threat to his 7,000 clients and made him a "menace to the public health." (AP Photo/Justin Juozapavicius)

This photo taken Thursday, March 28, 2013 shows the office of oral surgeon W. Scott Harrington in Tulsa, Okla. Health officials have urged Harrington?s patients to undergo hepatitis and HIV testing, saying filthy conditions at his office posed a threat to his 7,000 clients and made him a "menace to the public health." (AP Photo/Justin Juozapavicius)

Map locates city where health officials are urging 7000 patients of Oklahoma dentist Dr. W. Scott Harrington to seek testing for hepatitis or HIV.

Susan Rogers, executive director of the Oklahoma Board of Dentistry, speaks during a news conference regarding the practices of Tulsa oral surgeon Wayne Harrington, at the Tulsa Health Department's James O. Goodwin Health Center in Tulsa, Okla., on Thursday, March 28, 2013. Health officials said that thousands of Harrington's patients should undergo testing for HIV and hepatitis after officials looking into the source of a patient's viruses discovered the dentist's instruments weren't being cleaned properly. (AP Photo/Tulsa World, Cory Young) ONLINE OUT; TV OUT; TULSA OUT

(AP) ? Health officials on Thursday urged an Oklahoma oral surgeon's patients to undergo hepatitis and HIV testing, saying filthy conditions behind his office's spiffy facade posed a threat to his 7,000 clients and made him a "menace to the public health."

State and county health inspectors went to Dr. W. Scott Harrington's practice after a patient with no known risk factors tested positive for both hepatitis C and the virus that causes AIDS. They found employees using dirty equipment, reusing needles and administering drugs without a license.

Harrington voluntarily gave up his license and closed his offices in Tulsa and suburban Owasso and is cooperating with investigators, said Kaitlin Snider, a spokeswoman for the Tulsa Health Department. He faces a hearing April 19 where his license could be permanently revoked.

"This is an unprecedented event," Susan Rogers, executive director of the state Board of Dentistry, said in an interview. "To my knowledge, this has never happened before as far as a public notification of a (hepatitis C) case involving a dental office."

The Oklahoma Board of Dentistry said the inspectors discovered multiple sterilization issues at Harrington's offices, including the use of a separate, rusty, set of instruments for patients who were known to carry infectious diseases.

"The CDC (Centers for Disease Control and Prevention) has determined that rusted instruments are porous and cannot be properly sterilized," the board said in a 17-count complaint against the dentist.

Officials are sending letters to 7,000 people who are known to have been patients of Harrington, but they noted that they do not have information for patients before 2007. The letters urge the patients to be tested for hepatitis B, hepatitis C and HIV. ? viruses typically spread through intravenous drug use or unprotected sexual contact, not occupational settings.

"It's uncertain how long those practices have been in place," Snider said. "He's been practicing for 36 years."

Harrington could not be reached for comment Thursday. A message at his Tulsa office said it was closed and the doctor's answering service referred callers to the Tulsa Health Department. Phone numbers listed for Harrington were disconnected. A message left with Harrington's malpractice attorney in Tulsa, Jim Secrest II, was not immediately returned.

Harrington's practice in Tulsa is in a tony part of town, on a row of some of the city's most upscale medical practices. The white-and-green stucco, two-story dental clinic has the doctor's name in fancy letters on the facade.

Inside, the Dentistry Board said, Harrington ran a clinic that paid little attention to ensuring items were sterile. Dental assistants needing an extra dose of an anesthetic would re-insert used needles into drug vials, drug vials were used on multiple patients, the office had no written infection-protection procedure and Harrington told officials he left questions about sterilization and drug procedures to his employees.

"They take care of that, I don't," the board quoted him as saying.

The doctor is also accused of letting his assistants perform tasks only a licensed dentist should have done. Also, the complaint says that the doctor's staff could not produce permits for the assistants when asked for them.

Rogers said that as an oral surgeon, Harrington routinely does invasive procedures that involve "pulling teeth, open wounds, open blood vessels." The Dentistry Board complaint said Harrington and his staff told investigators that a "high population of known infectious disease carrier patients" received dental care from him.

According to the complaint, a device used to sterilize instruments wasn't working properly. A test is supposed to be performed monthly and sent to a lab to determine that the equipment is successfully sterilizing instruments, but "no such test had ever been performed in the 6 years one dental assistant had been working at the office," the complaint said.

The doctor also apparently used outdated drugs, as one vial found this year had an expiration date of 1993, and didn't properly keep track of drugs, the complaint said. It noted that a drug cabinet was unlocked and unattended during the day and that dental assistants administered IV sedation for procedures without the doctor being present.

It also said that although U.S. Drug Enforcement Administration records show Harrington had not received morphine from a distributor since 2009, the drug logs kept by his assistants said morphine had been used on patients intermittently throughout 2012.

Officials said patients will be offered free medical testing at the Tulsa Health Department's North Regional Health and Wellness Center.

Most people who become infected by hepatitis C get it by sharing needles or other equipment to inject drugs, according to the CDC's website. The infection can last a lifetime and lead to scarring of the liver or liver cancer.

Most people who get hepatitis B have it for a short time, though it can cause a long-term infection that can damage the liver. It can be transmitted through unprotected sex and sharing needles.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/386c25518f464186bf7a2ac026580ce7/Article_2013-03-28-Dentist%20Investigation-Testing/id-29a2834fa7b2454e8b0d0eb2b275e10f

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Pope Francis changes up Holy Thursday tradition

ROME (AP) ? Pope Francis washed and kissed the feet of a dozen inmates at a juvenile detention center in a Holy Thursday ritual that he celebrated for years as archbishop and is continuing now that he is pope. Two of the 12 were young women, a remarkable choice given that the church's current liturgical law says only men should participate.

The Mass was held in the Casal del Marmo facility in Rome, where 46 young men and women currently are detained. Many of them are Gypsies or North African migrants, and the 12 selected for the foot-washing rite included Orthodox and Muslim detainees, news reports said.

Because the inmates were mostly minors ? the facility houses inmates aged 14-to-21 ? the Vatican and Italian Justice Ministry limited media access inside. But Vatican Radio carried the Mass live, and Francis told the detainees that Jesus washed the feet of his disciples on the eve of his crucifixion in a gesture of love and service.

"This is a symbol, it is a sign ? washing your feet means I am at your service," Francis told the youngsters. "Help one another. This is what Jesus teaches us. This is what I do. And I do it with my heart. I do this with my heart because it is my duty, as a priest and bishop I must be at your service."

Later, the Vatican released a limited video of the ritual, showing Francis washing black feet, white feet, male feet, female feet and even a foot with tattoos. Kneeling on the stone floor as the 12 youngsters sat above him, the 76-year-old Francis poured water from a silver chalice over each foot, dried it with a simple cotton towel and then bent over to kiss each one.

As archbishop of Buenos Aires, the former Cardinal Jorge Mario Bergoglio would celebrate the ritual foot-washing in jails, hospitals or hospices ? part of his ministry to the poorest and most marginalized of society. It's a message that he is continuing now that he is pope, saying he wants a church "for the poor."

Previous popes would carry out the foot-washing ritual on Holy Thursday in Rome's grand St. John Lateran basilica. The 12 people chosen for the ritual would always be priests to represent Christ's 12 apostles.

That Francis would include women in this re-enactment is remarkable given current liturgical rules that restrict the ritual to men.

Canon lawyer Edward Peters, who is an adviser to the Holy See's top court, noted in a blog that the Congregation for Divine Worship in 1988 said in a letter to bishops that "The washing of the feet of chosen men ... represents the service and charity of Christ who came 'not to be served, but to serve.'"

Peters noted that bishops over the years have successfully petitioned Rome for an exemption to allow women to participate, but that the law on the issue is clear.

"By disregarding his own law in this matter, Francis violates, of course, no divine directive," Peters wrote Thursday. "What he does do, I fear, is set a questionable example."

Others welcomed the example he set.

"The pope's washing the feet of women is hugely significant because including women in this part of the Holy Thursday Mass has been frowned on ? and even banned ? in some dioceses," said the Rev. James Martin, a Jesuit priest and author of "The Jesuit Guide."

"It shows the all-embracing love of Christ, who ministered to all he met: man or woman, slave or free, Jew or Gentile," he said.

After the Mass, Francis greeted each of the inmates and gave each one an Easter egg.

"Don't lose hope," he said. "Understand? With hope you can always go on."

One of the inmates then asked him why he had come to visit them. Francis said it was to "help me to be humble, as a bishop should be." He said he wanted to come "from my heart. Things from the heart don't have an explanation," he said.

Italian Justice Minister Paola Severino, who has made easing Italy's woefully overcrowded prisons a priority, attended the Mass.

___

Follow Nicole Winfield at www.twitter.com/nwinfield

Source: http://news.yahoo.com/pope-washes-feet-young-detainees-ritual-173757747.html

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How The Internet Is Making Us Poor - Business Insider

Everyone knows the story of how robots replaced humans on the factory floor. But in the broader sweep of automation versus labor, a trend with far greater significance for the middle class?in rich countries, at any rate?has been relatively overlooked: the replacement of knowledge workers with software.

One reason for the neglect is that this trend is at most thirty years old, and has become apparent in economic data only in perhaps the past ten years. The first all-in-one commercial microprocessor went on sale in 1971, and like all inventions, it took decades for it to become an ecosystem of technologies pervasive and powerful enough to have a measurable impact on the way we work.

This feature is Part II in a series on the rise of the machines. You can read Part I, on the usurpation by robots of the last of the world?s unskilled manufacturing jobs, here.

?Software is eating the world?

Bloomberg TV

Marc Andreessen is funding the companies making the software disrupting labor markets the world over.


Sixty percent of the jobs in the US are information-processing jobs, notes Erik Brynjolfsson, co-author of a recent book about this disruption, Race Against the Machine. It?s safe to assume that almost all of these jobs are aided by machines that perform routine tasks. These machines make some workers more productive. They make others less essential.

The turn of the new millennium is when the automation of middle-class information processing tasks really got under way, according to an analysis by the Associated Press based on data from the Bureau of Labor Statistics. Between 2000 and 2010, the jobs of 1.1 million secretaries were eliminated, replaced by internet services that made everything from maintaining a calendar to planning trips easier than ever. In the same period, the number of telephone operators dropped by 64%, travel agents by 46% and bookkeepers by 26%. And the US was not a special case. As the AP notes, ?Two-thirds of the 7.6 million middle-class jobs that vanished in Europe were the victims of technology, estimates economist Maarten Goos at Belgium?s University of Leuven.?

Economist Andrew McAfee, Brynjolfsson?s co-author, has called these displaced people ?routine cognitive workers.? Technology, he says, is now smart enough to automate their often repetitive, programmatic tasks.??We are in a desperate, serious competition with these machines,? concurs Larry Kotlikoff, a professor of economics at Boston University. ?It seems like the machines are taking over all possible jobs.?

Like farming and factory work before it, the labors of the mind are being colonized by devices and systems. In the early 1800?s, nine out of ten Americans worked in agriculture?now it?s around 2%. At its peak, about a third of the US population was employed in manufacturing?now it?s less than 10%. How many decades until the figures are similar for the information-processing tasks that typify rich countries? post-industrial economies?

Web pioneer and venture capitalist Marc Andreessen describes this process as ?software is eating the world.? As he wrote in an editorial?(paywall) for the Wall Street Journal, ?More and more major businesses and industries are being run on software and delivered as online services?from movies to agriculture to national defense.?

The hollowing out of the middle class

To see how the internet has disproportionately affected the jobs of people who process information, check out the gray bars dipping below the 0% line on the chart, below. (I?ve adapted this chart to show just the types of employment that lost jobs in the US during the great recession. Every other category continued to add jobs or was nearly flat.)

People who process information are losing their jobs at rates comparable to the rate of loss in manufacturing.St. Louis Fed

What?s apparent is that the same trend seen in making and processing things?represented by the ?Production?? and ?Operators?? categories?shows up for the routine cognitive workers in offices and, for related if not identical reasons, sales.

Here?s another clue about what?s been going on in the past ten years. ?Return on capital? measures the return firms get when they spend money on capital goods like robots, factories, software?anything aside from people. (If this were a graph of return on people hired, it would be called ?Return on labor?.)

Not surprisingly, information processing tasks benefit as much from the application of capital?including information technology?as manufacturing does.St. Louis Fed

Notice: the only industry where the return on capital is as great as manufacturing is ?other industries??a grab bag which includes all the service and information industries, as well as entertainment, health care and education. In short, you don?t have to be a tech company for investing in technology to be worthwhile.

Companies that invest in IT do better

Here?s yet a third clue about what?s going on. For many years, the question of whether or not spending on information technology (IT) made companies more productive was highly controversial. Many studies found that IT spending either had no effect on productivity or was even counter-productive. But now a clear trend is emerging. More recent studies show that IT?and the organizational changes that go with it?are doing firms, especially multinationals?(pdf), a great deal of good.

One reason for the delay is that it has taken some time for companies to learn how best to use IT. Economist Carlota Perez calls this the ?installation phase.? Moreover, the more recent rise of the internet has multiplied the power that IT has on its own.

In any case, if computers are the factory floor for routine cognitive workers, then when software and the internet makes some workers more productive, others are no longer needed.

Winner-take-all, the power of capital to exacerbate inequality

One thing all our machines have accomplished, and especially the internet, is the ability to reproduce and distribute good work in record time. Barring market distortions like monopolies, the best software, media, business processes and, increasingly, hardware, can be copied and sold seemingly everywhere at once. This benefits ?superstars??the most skilled engineers or content creators. And it benefits the consumer, who can expect a higher average quality of goods.

But it can also exacerbate income inequality, says Brynjolfsson. This contributes to a phenomenon called ?skill-biased technological [or technical] change.? ?The idea is that technology in the past 30 years has tended to favor more skilled and educated workers versus less educated workers,? says Brynjolfsson. ?It has been a complement for more skilled workers. It makes their labor more valuable. But for less skilled workers, it makes them less necessary?especially those who do routine, repetitive tasks.?

The result is that, with the aid of machines, productivity increases?the overall economic pie gets bigger?but that?s small consolation if all but a few workers are getting a smaller slice. ?Certainly the labor market has never been better for very highly-educated workers in the United States, and when I say never, I mean never,? MIT labor economist David Autor told American Public Media?s Marketplace.

The other winners in this scenario are anyone who owns capital. Only about half of Americans own stock at all, and as more companies are taken private or never go public, more and more of that wealth is concentrated in the hands of fewer and fewer people. As Paul Krugman wrote, ?This is an old concern in economics; it?s ?capital-biased technological change?, which tends to shift the distribution of income away from workers to the owners of capital.?

Unlike other technological revolutions, computers are everywhere

The ubiquity of smartphones in rich countries is just the tip of the silicon iceberg. Computers are more disruptive than, say, the looms smashed by the Luddites, because they are ?general-purpose technologies? noted Peter Linert, an economist at University of Californa-Davis. Sensors, embedded systems, internet-connected devices, and an ever-expanding pool of cloud computing resources are all being put to the same use: how to figure out, in the most efficient way possible, what to do next.

?The spread of computers and the Internet will put jobs in two categories,? said Andreessen. ?People who tell computers what to do, and people who are told by computers what to do.? It?s a glib remark?but increasingly true.

In a gleaming new warehouse in the old market town of Rugley, England, Amazon directs the actions of hundreds of ?associates? wielding hand-held computers. These computers tell workers not only which shelf to walk to when they?re pulling goods to be shipped, but also the optimal route by which to get there. Each person?s performance is monitored, and they are given constant feedback about whether or not they are performing their job quickly enough. Their bosses can even send them text messages via their handheld computers, urging them to speed up. ?You?re sort of like a robot, but in human form,? one manager at Amazon?s warehouse told the Financial Times. ?It?s human automation, if you like.?

And yet despite this already high level of automation, Amazon is already working on how to eliminate the humans in its warehouses all together. In March 2009, Amazon acquired Kiva Systems, a warehouse robotics and automation company. In partnership with a company called Quiet Logistics, Kiva?s combination of mobile shelving and robots has already automated a warehouse in Andover, Massachusetts. Here?s a video showing how Kiva?s robots, which look like oversize Roombas, can store, retrieve and sort goods with minimal involvement from humans.

This time it?s faster

History is littered with technological transitions. Many of them seemed at the time to threaten mass unemployment of one type of worker or another, whether it was buggy whip makers or, more recently, travel agents. But here?s what?s different about information-processing jobs: The takeover by technology is happening much faster.

From 2000 to 2007, in the years leading up to the great recession, GDP and productivity in the US grew faster than at any point since the 1960s, but job creation did not keep pace. Brynjolfsson thinks he knows why: More and more people were doing work aided by software. And during the great recession, employment growth didn?t just slow. As we saw above, in both manufacturing and information processing, the economy shed jobs, even as employment in the service sector and professional fields remained flat.

Especially in the past ten years, economists have seen a reversal of what they call ?the great compression??that period from the second world war through the 1970s when, in the US at least, more people were crowded into the ranks of the middle class than ever before. There are many reasons why the economy has reversed this ?compression,? transforming into an ?hourglass economy? with many fewer workers in the middle class and more at either the high or the low end of the income spectrum. But whatever those forces, they are clearly being exacerbated by technological change.

The hourglass represents an income distribution that has been more nearly the norm for most of the history of the US. That it?s?coming back should worry anyone who believes that a healthy middle class is an inevitable outcome of economic progress, a mainstay of democracy and a healthy society, or a driver of further economic development. Indeed, some have argued that as technology aids the gutting of the middle class, it destroys the very market required to sustain it?that we?ll see ?less of the type of innovation we associate with Steve Jobs, and more of the type you would find at Goldman Sachs.?

Is any job safe?

Recently I sat down with the team at Betterment, a tech startup to which people have already handed over $150 million in assets. For many, that money represents a significant chunk of their savings and retirement accounts. Betterment is the sort of company that, it it does well, will someday be a canonical example of the principle that ?software eats everything.? It?s an attempt replace the kind of job you might think is still beyond the reach of an algorithm: personal financial advice.

The legal field has been transformed by software too. For example, it replaced paralegals in the previously labor-intensive process of sifting through documents during the discovery phase of a lawsuit.

No one, it seems, is more aware of this phenomenon than the technologists themselves. In an interview with Pando Daily, Josh Kopelman, a venture capitalist with First Round Capital, said that even his industry is going to be eaten by software. ?In fifteen years, will VCs make as much money as they do now?? he was asked. ?They probably shouldn?t,? was his response.

Survival of the fittest?and the richest

Barring a civilization-ending event, technology is not going to move backward. More and more of our world will be controlled by software. It?s already become so ubiquitous that, argues one of my colleagues, it?s now ridiculous to call some firms as ?tech? companies when all companies depend on it so much.

So how do we deal with this trend? The possible solutions to the problems of disruption by thinking machines are beyond the scope of this piece. As I?ve mentioned in other pieces published at Quartz, there are plenty of optimists ready to declare that the rise of the machines will ultimately enable higher standards of living, or at least forms of unemployment as foreign to us as ?big data scientist? would be to a scribe of the 17th century.

But that?s only as long as you?re one of the ones telling machines what to do, not being told by them. And that will require self-teaching, creativity, entrepreneurialism and other traits that may or may not be latent in children, as well as retraining adults who aspire to middle class living. For now, sadly, your safest bet is to be a technologist and/or own capital, and use all this automation to grab a bigger-than-ever share of a pie that continues to expand.

Source: http://www.businessinsider.com/how-the-internet-is-making-us-poor-2013-3

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Seven sexes!? Scientists figure out how these microbes juggle mates

The ASSET Program / Cornell

An image produced by a scanning electron microscope shows two Tetrahymena cells in the act of mating.

By Alan Boyle, Science Editor, NBC News

Biologists have known for decades that there are up to seven sexes of the single-celled organism known as Tetrahymena thermophila ? but they didn't know exactly how those different sexes "did it." Until now.

When it's time for Tetrahymena to mate, two organisms of different mating types recognize each other and get together to swap DNA. The results of the hookup are totally random. One critter may be mating type No. 1, the other may be mating type No. 3, and the two resulting progeny may turn out to be, um, mating type No. 6. How do they do that?

In the journal PLOS Biology, researchers report that the hooked-up organisms almost literally roll the genetic dice to determine what the sex of the progeny will be.


The researchers say the key to Tetrahymena's sexual proclivities lies in its double genome: Every cell has a "somatic" genome that manages its everyday life, plus a "germline" genome that serves a function similar to that of the ovaries or testes in humans. The germline genome contains incomplete gene pairs for each of six or seven sexes, depending on the cell line. (In this case, the cells came in six sexual flavors.)

Random sex
When two microbes hook up, the progeny's newly created somatic genome latches onto one of those incomplete gene pairs, producing one complete sex-specific gene pair. The other sexy bits from the germline genome are wiped out. The random rearrangement leaves the resulting cells with exactly one complete sex-specific gene pair ? and one mating type.

"It's completely random, as if they had a roulette wheel with six numbers, and wherever the marble ends up is what they get," senior researcher Eduardo Orias, a research professor emeritus at the University of California at Santa Barbara, explained in a news release. "By chance they may have the same mating type as the parents ? but it's only by chance. It's a fascinating system."

Most of the time, Tetrahymena reproduces asexually, simply by having a parent cell divide into two progeny cells. But the organisms tend to pair up sexually when food is scarce, apparently as part of an evolutionary mechanism that takes advantage of genetic diversity. Sex-specific proteins on the surface of the cells serve as a signal that mating is likely to result in more diverse progeny. That's how two cells of the same mating type avoid pairing up with each other.

This type of mating process doesn't by itself increase the Tetrahymena population: Two cells hook up, and after recombining DNA, two cells separate again. "This is sex without reproduction," Orias said during a telephone interview. After mating, the recombined genetic information is passed down from parents to progeny through asexual reproduction ??until it's time for the next hookup.

What it means for humans
Although the process sounds totally alien to us two-sex types, the lessons from Tetrahymena could have implications for human health.

"Tetrahymena has about as many genes as the human genome," Orias said in the news release. "For thousands of those genes, you can recognize the sequence similarity to corresponding genes in the human genome with the same biological function. That's what makes it a valuable organism to investigate important biological questions."

For example, Tetrahymena may reveal new tricks relating to the methods that cells use to recognize friend vs. foe. That could have implications for studying human immune response. Also, the way that the organisms rearrange their DNA may point to new strategies for fighting cancer, which often results from the faulty rearrangement of genetic material.

"The hope is that at some point, there may be useful applications for medicine," Orias told NBC News.

More about microbial marvels:


In addition to Orias, the authors of "Selecting One of Several Mating Types Through Gene Segment Joining and Deletion in Tetrahymena Thermophila" include Marcella D. Cervantes, Eileen P. Hamilton, Jie Xiong, Michael J. Lawson, Dongxia Yuan, Michalis Hadjitomas and Wei Miao.

Alan Boyle is NBCNews.com's science editor. Connect with the Cosmic Log community by "liking" the log's?Facebook page, following?@b0yle on Twitter?and adding the?Cosmic Log page?to your Google+ presence. To keep up with Cosmic Log as well as NBCNews.com's other stories about science and space, sign up for the Tech & Science newsletter, delivered to your email in-box every weekday. You can also check out?"The Case for Pluto,"?my book about the controversial dwarf planet and the search for new worlds.

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Quantum computing? Physicists' new technique for cooling molecules may be a stepping stone to quantum computing

Mar. 27, 2013 ? The next generation of computers promises far greater power and faster processing speeds than today's silicon-based based machines. These "quantum computers" -- so called because they would harness the unique quantum mechanical properties of atomic particles -- could draw their computing power from a collection of super-cooled molecules.

But chilling molecules to a fraction of a degree above absolute zero, the temperature at which they can be manipulated to store and transmit data, has proven to be a difficult challenge for scientists.

Now, UCLA physicists have pioneered a new technique that combines two traditional atomic cooling technologies and brings normally springy molecules to a frozen standstill. Their research is published March 28 in the journal Nature.

"Scientists have been trying to cool molecules for a decade and have succeeded with only a few special molecules," said Eric Hudson, a UCLA assistant professor of physics and the paper's senior author. "Our technique is a completely different approach to the problem -- it is a lot easier to implement than the other techniques and should work with hundreds of different molecules."

Previous attempts to create ultracold molecules were only effective with one or two specific kinds. Creating a method that can be used with many different molecules would be a major step forward because it is difficult to say which materials might be used in quantum computers or other future applications, Hudson said.

By immersing charged barium chloride molecules in an ultracold cloud of calcium atoms, Hudson and his colleagues are able to prevent most of the molecules from vibrating and rotating. Halting the molecules is a necessary hurdle to overcome before they can be used to store information like a traditional computer does.

"The goal is to build a computer that doesn't work with zeros and ones, but with quantum mechanical objects," Hudson said. "A quantum computer could crack any code created by a classical computer and transmit information perfectly securely."

Hudson's experiment makes molecules extremely cold under highly controlled conditions to reveal the quantum mechanical properties that are hidden under normal circumstances. At room temperature, molecules rocket around, bouncing into each other and exchanging energy. Any information a scientist attempted to store in such a chaotic system would quickly become gibberish.

"We isolate these molecular systems in a vacuum, effectively levitating them in the middle of nothing," Hudson said. "This removes them from the rest of the world that wants to make them classical."

The quantum mechanical world of subatomic particles deviates from the classical world that we observe with the naked eye because according to quantum mechanics, electrons can only exist at specific energy levels. In a quantum computer made of a collection of single atoms, information might be stored by boosting some atomic electrons to higher energy levels while leaving others at lower energy states. However, these atomic energy states are not stable enough to reliably preserve data, Hudson said.

"One of the challenges with atoms is that their energy states are very easily influenced by the outside world," Hudson said. "You make this beautiful quantum state, but then the outside world tries to destroy that information."

Instead of saving data in easily disrupted atomic energy states, a more robust way to store information is in the rotational energy states of molecules, Hudson said. A spinning molecule in the lowest energy rotational state could represent a binary one, while a stationary molecule could represent a binary zero.

Despite applications for quantum computing and other industries, cooling molecules to extremely low temperatures has proved a challenge. Even the simplest molecule composed of only two atoms is a far more complex system than a single atom. Each molecule vibrates and rotates like a miniature whirling slinky, and all of that movement must be stilled so that the molecule can lose energy and cool down.

A new cooling technique

To solve the ultracold molecule conundrum, Hudson and his group first created a floating cloud of calcium atoms corralled by incoming laser beams from all directions. This magneto-optical trap keeps the atoms stationary as it cools them to nearly absolute zero. They then use specialized rods with high, oscillating voltages as part of an ion trap to confine a cloud of positively-charged barium chloride molecules within the ultracold ball of calcium atoms to complete the cooling process.

For the vibrating, energetic molecules to lose heat, they must spend a significant amount of time in contact with the surrounding ultracold atom cloud. Hudson and his colleagues used barium chloride ions, molecules missing one electron, because charged molecules are easier to trap and cool than their neutral counterparts. The use of molecular ions is an essential innovation because previous efforts have demonstrated that neutral molecules ricochet off ultracold atoms without sufficient heat transfer.

"When a molecular ion and a neutral atom get close together they get in tight and bang off each other a bunch before the ion goes away," Hudson said. "When they collide like that it is very easy for the energy in one to go to the other."

While magneto-optical and ion traps are not new to the world of molecular physics, Hudson and his colleagues became the first group to combine these methods to create a cloud of ultracold molecules. This paper is the result of over four years of work spent designing, building, and testing their experiment.

"These two different technologies earned Nobel prizes for the scientists who developed them, but there wasn't really a body of knowledge about how to put these two procedures together," Hudson said.

The research is funded by the Army Research Office and the National Science Foundation.

Other co-authors include former UCLA postdoctoral scholar Wade Rellergert; UCLA graduate students Scott Sullivan, Steven Schowalter and Kuang Chen; and Temple University physics professor Svetlana Kotochigova.

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The above story is reprinted from materials provided by University of California - Los Angeles. The original article was written by Kim DeRose.

Note: Materials may be edited for content and length. For further information, please contact the source cited above.


Journal Reference:

  1. Wade G. Rellergert, Scott T. Sullivan, Steven J. Schowalter, Svetlana Kotochigova, Kuang Chen, Eric R. Hudson. Evidence for sympathetic vibrational cooling of translationally cold molecules. Nature, 2013; 495 (7442): 490 DOI: 10.1038/nature11937

Note: If no author is given, the source is cited instead.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/top_news/~3/SYUzrzW3LIc/130327144129.htm

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